The very thing that makes botox different is also the reason no wrinkle cream can compare with its results. Wrinkles do not start on the surface but beneath it. Creams, dermal abrasions and other topical treatments cannot hope to have much of an effect on things that are happening beneath the dermis.
Wrinkles start below the surface in the muscles. This is much farther than any surface treatment can penetrate. Yes, well moisturized skin has less visible wrinkles but that is only a pacifying move. As soon as the skin dries the wrinkles will reappear. The truth is there is not one cream on the market that works as good as or better than or just like botox.